NFkB p50 polyclonal, anti-human, mouse, rat antibody
€275.00
In stock
SKU
AC-ABV10259-100
Catalog Number: AC-ABV10259-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
Request Information
Background:
Nuclear factor kappa B (NFkB) was identified as a sequence specific transcriptional activator that binds to the intronic enhancer of kappa light chain gene in B lymphocytes. NFkB is a heterodimer that consists of a 50 kDa DNA binding subunit (p50) and a 65 kDa transactivation subunit (p65/RelA). Both of these subunits exhibit sequence homology to the protooncogene c-Rel. The p50 has an isoform called p49/p52, and both proteins are derived from the amino-terminal of precursor protein p105 and p100. The p50/p65 heterodimer remains in the cytosol in an inactive form as a complex with its inhibitor, IkB. Upon stimulation of cells by a wide variety of stimuli such as lipopolysaccharide (LPS), pro-inflammatory cytokines (IL-1 & TNF, etc.), and viral infection, IkB is phosphorylated and degraded by proteosome. The active NFkB heterodimer is translocated into the nucleus and induces gene expression.
Other Names:
NFkBp50, NFkB p50, NF-kBp50, NF-kB p50, NFkappaB p50, NFKB1, NFKB-p105 , NFKB-p50 , NF-kappa-B , EBP-1, MGC54151, DKFZp686C01211
Primary Accession: P19838
Other Accession: BAF84139.1
Gene Name: NFKB1
Gene ID: 4790
Concentration (mg/ml): 0.5 mg/ml
Nuclear factor kappa B (NFkB) was identified as a sequence specific transcriptional activator that binds to the intronic enhancer of kappa light chain gene in B lymphocytes. NFkB is a heterodimer that consists of a 50 kDa DNA binding subunit (p50) and a 65 kDa transactivation subunit (p65/RelA). Both of these subunits exhibit sequence homology to the protooncogene c-Rel. The p50 has an isoform called p49/p52, and both proteins are derived from the amino-terminal of precursor protein p105 and p100. The p50/p65 heterodimer remains in the cytosol in an inactive form as a complex with its inhibitor, IkB. Upon stimulation of cells by a wide variety of stimuli such as lipopolysaccharide (LPS), pro-inflammatory cytokines (IL-1 & TNF, etc.), and viral infection, IkB is phosphorylated and degraded by proteosome. The active NFkB heterodimer is translocated into the nucleus and induces gene expression.
Other Names:
NFkBp50, NFkB p50, NF-kBp50, NF-kB p50, NFkappaB p50, NFKB1, NFKB-p105 , NFKB-p50 , NF-kappa-B , EBP-1, MGC54151, DKFZp686C01211
Primary Accession: P19838
Other Accession: BAF84139.1
Gene Name: NFKB1
Gene ID: 4790
Concentration (mg/ml): 0.5 mg/ml
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