NFKB p50 polyclonal, anti-human, mouse, rat, dog, pig , bovine, chicken

Protein Family: Transcription Factors

Pathway and Disease: Signal Transduction, Cell Growth and Death, Immune System, Endocrine System, Development and Behavior, Nervous and Sensory Systems, Cancers, Infectious Diseases

Description:
NF-kappa-B p50 subunit (NFKB p50) is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, is subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3.

Alternate Names: Nuclear factor NF-kappa-B p105/p50 subunit, DNA-binding factor KBF1, EBP-1, NFKB1, Nuclear factor NF-kappa-B p50 subunit, NFKB p105/p50

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P19838

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human NFKB p50.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
Padiya R et al. 2014. PLoS One. 9(5): e94228. PMID# 24796753.