NFkB p65 (clone 2A12A7), anti-human, mouse, rat antibody
€370.00
In stock
SKU
AC-ABV10007-100
Catalog Number: AC-ABV10007-100
Size: 100 µg
Host: Mouse IgG
Applications: WB, IHC, IP
Datasheet
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Size: 100 µg
Host: Mouse IgG
Applications: WB, IHC, IP
Datasheet
Request Information
Background:
NFkB was identified as a sequence specific transcriptional activator that binds to the intronic enhancer of kappa light chain gene in B lymphocytes. NFkB is a heterodimer that consists of a 50 kDa DNA binding subunit (p50) and a 65 kDa transactivation subunit (p65/RelA). Both of these subunits exhibit sequence homology to the protooncogene c-Rel. The p50/p65 heterodimer remains in the cytosol in an inactive form as a complex with its inhibitor, IkB. Upon stimulation of cells by a wide variety of stimuli such as lipopolysaccharide (LPS), pro-inflammatory cytokines, and viral infection. IkB is phosphorylated and degraded by proteosome. The active NFkB heterodimer is translocated into the nucleus and induces gene expression.
Other Names:
RELA, NFKB3, MGC131774
Primary Accession: Q04207
Other Accession: NP_033071
Gene Name: Rela
Gene ID: 19697
Concentration (mg/ml): 0.2 mg/ml
NFkB was identified as a sequence specific transcriptional activator that binds to the intronic enhancer of kappa light chain gene in B lymphocytes. NFkB is a heterodimer that consists of a 50 kDa DNA binding subunit (p50) and a 65 kDa transactivation subunit (p65/RelA). Both of these subunits exhibit sequence homology to the protooncogene c-Rel. The p50/p65 heterodimer remains in the cytosol in an inactive form as a complex with its inhibitor, IkB. Upon stimulation of cells by a wide variety of stimuli such as lipopolysaccharide (LPS), pro-inflammatory cytokines, and viral infection. IkB is phosphorylated and degraded by proteosome. The active NFkB heterodimer is translocated into the nucleus and induces gene expression.
Other Names:
RELA, NFKB3, MGC131774
Primary Accession: Q04207
Other Accession: NP_033071
Gene Name: Rela
Gene ID: 19697
Concentration (mg/ml): 0.2 mg/ml
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