NFKB1 antibody (clone 2000000), anti-human
€435.00
In stock
SKU
AC-AT3035a
Catalog Number: AC-AT3035a
Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, IF
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Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, IF
Request Information AC-AT3035a">Request Information
Background:
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.
Other Names:
Nuclear factor NF-kappa-B p105 subunit, DNA-binding factor KBF1, EBP-1, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, Nuclear factor NF-kappa-B p50 subunit, NFKB1
Antigen Type:
Recombinant Protein
Gene Name: NFKB1
Gene ID: 4790
NCBI Accession: NP_001158884.1;NP_003989.2
Primary Accession: P19838
Other Accession: BC051765
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.
Other Names:
Nuclear factor NF-kappa-B p105 subunit, DNA-binding factor KBF1, EBP-1, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, Nuclear factor NF-kappa-B p50 subunit, NFKB1
Antigen Type:
Recombinant Protein
Gene Name: NFKB1
Gene ID: 4790
NCBI Accession: NP_001158884.1;NP_003989.2
Primary Accession: P19838
Other Accession: BC051765
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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