NFKB1 polyclonal (S932), anti-human
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In stock
SKU
AC-AP1980c
Catalog Number: AC-AP1980c
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB11204
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB11204
Applications: WB
Datasheet
Request Information
Background:
NFKB1 is a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth.
Other Names:
Nuclear factor NF-kappa-B p105 subunit, DNA-binding factor KBF1, EBP-1, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, Nuclear factor NF-kappa-B p50 subunit, NFKB1
Target/Specificity:
This NFKB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 911-939 amino acids from human NFKB1.
Antigen Region:
911-939
Antigen Type: Synthetic Peptide
Gene Name: NFKB1
Gene ID: 4790
Primary Accession: P19838
NCBI Accession: NP_001158884.1;NP_003989.2
Other Accession: P25799; Q04861
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
NFKB1 is a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth.
Other Names:
Nuclear factor NF-kappa-B p105 subunit, DNA-binding factor KBF1, EBP-1, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, Nuclear factor NF-kappa-B p50 subunit, NFKB1
Target/Specificity:
This NFKB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 911-939 amino acids from human NFKB1.
Antigen Region:
911-939
Antigen Type: Synthetic Peptide
Gene Name: NFKB1
Gene ID: 4790
Primary Accession: P19838
NCBI Accession: NP_001158884.1;NP_003989.2
Other Accession: P25799; Q04861
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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