NFKBID Polyclonal Antibody

Background:
May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR-induced negative selection of thymocytes.IκBNS, the nuclear IκB-like protein encoded by Nfkbid, is required for the development of marginal zone and peritoneal B-1 B cells and additionally required for extrafollicular antibody responses to T-independent and -dependent immunogens.IκBNS has been identified as a member of the IκB family of NF-κB inhibitors, which undergoes induction upon TCR signaling. IκBNS mediates both positive and negative gene regulation, depending on individual cell type and/or cytokine.

Research Area: Epigenetics and Nuclear Signaling, Immunology, Signal Transduction

Synonyms:
I-kappa-B-delta, IkappaBdelta, IkappaBNS, IkB-delta, IKBD, IKBNS, NF-kappa-B inhibitor delta, NFKBID, Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor delta, T-cell activation NFKB-like protein, TA-NFKBH

Immunogen: Recombinant protein of human NFKBID

Swissprot: Q8NI38
Gene Accession: BC006273

Calculated MW: 33 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.3 mg/mL
Dilution: WB 1:500-1:2000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.