NFKBIZ polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS71645
Background:
Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis.
Alternative Name:
NF-kappa-B inhibitor zeta, I-kappa-B-zeta, IkB-zeta, INAP, IKBZ, INAP, MAIL
Application Dilution: WB : 1:500 - 1:2000
Specificity: NFKBIZ polyclonal antibody detects endogenous levels of NFKBIZ protein.
Immunogen:
Recombinant protein of human NFKBIZ
MW: Predicted band size: 78 kDa, Observed band size: Refer to Figures
Swis Prot.: Q9BYH8
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis.
Alternative Name:
NF-kappa-B inhibitor zeta, I-kappa-B-zeta, IkB-zeta, INAP, IKBZ, INAP, MAIL
Application Dilution: WB : 1:500 - 1:2000
Specificity: NFKBIZ polyclonal antibody detects endogenous levels of NFKBIZ protein.
Immunogen:
Recombinant protein of human NFKBIZ
MW: Predicted band size: 78 kDa, Observed band size: Refer to Figures
Swis Prot.: Q9BYH8
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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