NFKBIZ Polyclonal Antibody

Background:
This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene.

Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism, Immunology

Synonyms:
FLJ30225, FLJ34463, I-kappa-B-zeta, Ikappa B zeta, IkappaB zeta, IkappaBzeta, IkB-zeta, IKBZ, IKBZ, IKBzeta, IL-1 inducible nuclear ankyrin-repeat protein, INAP, MAIL, MAIL protein, Molecule possessing ankyrin repeats induced by lipopolysaccharide, NF-kappa-B inhibitor zeta, NFKBIZ, Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor zeta

Immunogen: Synthetic peptide of human NFKBIZ

Swissprot: Q9BYH8
Gene Accession: NP001005474

Calculated MW: 78 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.7 mg/mL
Dilution: WB 1:500-1:2000, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.