NFX1 antibody (clone 1D12), anti-human
€435.00
In stock
SKU
AC-AT3039a
Catalog Number: AC-AT3039a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF, E
Request Information AC-AT3039a">Request Information
Background:
MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.
Other Names:
Transcriptional repressor NF-X1, 632-, Nuclear transcription factor, X box-binding protein 1, NFX1, NFX2
Antigen Type:
Recombinant Protein
Gene Name: NFX1
Gene ID: 4799
NCBI Accession: NP_002495.2;NP_667344.1
Primary Accession: Q12986
Other Accession: NM_002504
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified.
Other Names:
Transcriptional repressor NF-X1, 632-, Nuclear transcription factor, X box-binding protein 1, NFX1, NFX2
Antigen Type:
Recombinant Protein
Gene Name: NFX1
Gene ID: 4799
NCBI Accession: NP_002495.2;NP_667344.1
Primary Accession: Q12986
Other Accession: NM_002504
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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