NFX1 polyclonal antibody, anti-human, mouse

Background:
MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes| two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants| each of which encodes a different isoform| have been identified.

Research Area: Cell biology, Epigenetics and nuclear signaling, Immunology

Synonyms: Transcriptional repressor NF-X1 , EC 6.3.2.-, Nuclear transcription factor, X box-binding protein 1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year