NGEF polyclonal (C-term), anti-human
€0.00
In stock
SKU
AC-AP21607b
Catalog Number: AC-AP21607b
Size: 50 µl, 200 µl
Isotype: Rabbit IgG
Clone Name: RB53235
Applications: WB
Datasheet
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Size: 50 µl, 200 µl
Isotype: Rabbit IgG
Clone Name: RB53235
Applications: WB
Datasheet
Request Information
Background:
Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
Other Names:
Ephexin-1, Eph-interacting exchange protein, Neuronal guanine nucleotide exchange factor, NGEF
Target/Specificity:
This NGEF antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 669-704 amino acids from the C-terminal region of human NGEF.
Gene Name: NGEF
Gene ID: 25791
Primary Accession: Q8N5V2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
Other Names:
Ephexin-1, Eph-interacting exchange protein, Neuronal guanine nucleotide exchange factor, NGEF
Target/Specificity:
This NGEF antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 669-704 amino acids from the C-terminal region of human NGEF.
Gene Name: NGEF
Gene ID: 25791
Primary Accession: Q8N5V2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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