NGF-beta polyclonal, anti-human, mouse, rat

Protein Family: Cytokines

Pathway and Disease: Cell Growth and Death, Nervous and Sensory Systems, Signal Transduction

Description:
Nerve growth factor (NGF) is important for the development , differentation, and survival of a variety of neuronal and non-neuronal cells. NGF action is mediated by binding to two distinct receptors, the high affinity p140 and low affinity p75 NGF receptors. P75NGFR binds neurotrophins including brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin 4/5 (NT-4/5) and NT-6. p75NGFR belongs to the TNF-R superfamily reported to mediate NGF-induced apoptosis. Defects in NGF are the cause of hereditary sensory and autonomic neuropathies.

Alternate Names: Beta-nerve growth factor, beta-NGF, NGF, NGFB

Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500

Accession No.: P01138

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human NGF.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.1 mg/ml BSA, 50% glycerol with 0.09% sodium azide. Antibody was purified by Protein-A and peptide-affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.