NGF-Receptor (p75) / CD271 (Soft Tissue Tumor Marker) (clone SPM299 ), anti-human, rabbit, primate, baboon, cat
€0.00
In stock
SKU
AC-AH12009
Catalog Number: AC-AH12009
Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: SPM299
Applications: IHC, IF, FC
Datasheet
Request Information
Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: SPM299
Applications: IHC, IF, FC
Datasheet
Request Information
Background:
It recognizes a glycoprotein of 75kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR). Its epitope spans in aa 1-160 of extracellular domain of NGFR/NTR. NGF-receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGF is important for the development, differentiation, and survival of variety of neuronal and non-neuronal cells. Its action is mediated by binding two distinct receptors, the high affinity p140 and low affinity p75.
Other Names:
Tumor necrosis factor receptor superfamily member 16, Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, NGF receptor, p75 ICD, CD271, NGFR, TNFRSF16
Gene Name: NGFR
Gene ID: 4804
Primary Accession: P08138
Other Accession: 4804, 415768, 681726
It recognizes a glycoprotein of 75kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR). Its epitope spans in aa 1-160 of extracellular domain of NGFR/NTR. NGF-receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGF is important for the development, differentiation, and survival of variety of neuronal and non-neuronal cells. Its action is mediated by binding two distinct receptors, the high affinity p140 and low affinity p75.
Other Names:
Tumor necrosis factor receptor superfamily member 16, Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, NGF receptor, p75 ICD, CD271, NGFR, TNFRSF16
Gene Name: NGFR
Gene ID: 4804
Primary Accession: P08138
Other Accession: 4804, 415768, 681726
| Is Featured? | No |
|---|
Write Your Own Review