NHRF1 polyclonal antibody, anti-human, mouse, rat

Background:
This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles| microvilli| and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2| and loss of heterozygosity of this gene is implicated in breast cancer.

Research Area: Signal transduction, Cancer, Tags & cell markers

Synonyms: Na, +/H, + exchange regulatory cofactor NHE-RF1 , NHERF-1, Ezrin-radixin-moesin-binding phosphoprotein 50, EBP50, Regulatory cofactor of Na, +/H, + exchanger, Sodium-hydrogen exchanger regulatory f

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year