Nicastrin polyclonal, anti-human

Background:
The Presenilin 1 (PS1) and Presenilin 2 (PS2) transmembrane proteins are components of high molecular weight complexes. These complexes mediate proteolytic cleavage within the transmembrane domain of several proteins, including the β-Amyloid precursor protein (βAPP) and Notch. Missense mutations in the genes encoding the Presenilin proteins increase the proteolysis of βAPP and results in the overproduction of the neurotoxic β-Amyloid peptide, which results in a condition associated with Familial Alzheimer's disease (FAD). A novel component of the presenilin complex, nicastrin, is a type I transmembrane glycoprotein that is involved in mediating Notch/GLP-1 signaling. In addition, nicastrin contributes to the processing of βAPP, which makes nicastrin an attractive potential target for modulating the production of β-Amyloid in patients with Alzheimer's disease. Originally purified from immunoprecipitated PS1 complexes from HEK293 cells, nicastrin contains hydrophilic amino and carboxy-terminal domains, a short, hydrophobic transmembrane domain and potential N-myristoylation and phosphorylation sites.

Alternative Name:
NCSTN, KIAA0253, Anterior pharynx defective 2, APH 2, APH2, ATAG1874, KIAA0253, Ncstn, NCT, NICA, Nicastrin, RP11 517F10.1, RP11517F101,

Application Dilution:
WB:1:500-1:1,000

Specificity: Nicastrin polyclonal antibody detects endogenous levels of Nicastrin protein.

Immunogen:
Synthetic peptide within Human Nicastrin aa 650-750 (C terminal).

MW: 78 kDa

Swiss-Prot: Q92542(Human)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.