NIK polyclonal, anti-human, mouse, rat, hamster, dog antibody
€285.00
In stock
SKU
AC-ABV10159-100
Catalog Number: AC-ABV10159-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
Request Information
Background:
NIK (NF-kB-inducing kinase) is a member of the MAP kinase kinase kinase family that binds TRAF2 and stimulates NF-kB activity. NIK was initially isolated from a human B cell cDNA library and contains 795 amino acids with an apparent molecular weight of slightly more than 97 kDa on SDS gel. NIK is a serine/threonine kinase and its kinase activity contributes to IkB phosphorylation. The carboxyl terminal segment of NIK binds TRAF2. A mutant NIK with intact carboxyl terminus but without the two lysine residues at its catalytic domain serves as a dominant-negative inhibitor for NF-kB activation. NIK also interacts with TRAF6 and mediates IL-1-induced NF-kB activation.
Other Names:
MAP3K14, hsNIK, FTDCR1B, HSNIK , EC 2.7.11.25
Primary Accession: Q99558
Gene Name: MAP3K14
Gene ID: 9020
Concentration (mg/ml): 0.5 mg/ml
NIK (NF-kB-inducing kinase) is a member of the MAP kinase kinase kinase family that binds TRAF2 and stimulates NF-kB activity. NIK was initially isolated from a human B cell cDNA library and contains 795 amino acids with an apparent molecular weight of slightly more than 97 kDa on SDS gel. NIK is a serine/threonine kinase and its kinase activity contributes to IkB phosphorylation. The carboxyl terminal segment of NIK binds TRAF2. A mutant NIK with intact carboxyl terminus but without the two lysine residues at its catalytic domain serves as a dominant-negative inhibitor for NF-kB activation. NIK also interacts with TRAF6 and mediates IL-1-induced NF-kB activation.
Other Names:
MAP3K14, hsNIK, FTDCR1B, HSNIK , EC 2.7.11.25
Primary Accession: Q99558
Gene Name: MAP3K14
Gene ID: 9020
Concentration (mg/ml): 0.5 mg/ml
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