Nkx2.5 polyclonal, anti-human, mouse

Quantity: 100 µg

Background:
Homeobox protein Nkx-2.5, also known as NKX2E or CSX is a protein that in humans is encoded by the NKX2-5 gene. It is mapped to 5q35.1. Homeobox-containing genes play critical roles in regulating tissue-specific gene expression essential for tissue differentiation, as well as determining the temporal and spatial patterns of development. Nkx2.5 and Tbx5 directly bound to the promoter of the gene encoding cardiac-specific natriuretic peptide precursor type A (NPPA) in tandem, and both transcription factors showed synergistic activation. The cardiac homeobox protein Nkx2.5 is essential in cardiac development, and mutations in CSX (which encodes Nkx2.5) cause various congenital heart malformations.

Description:
Rabbit IgG polyclonal antibody for Homeobox protein Nkx-2.5 (NKX2-5) detection. Tested with WB in Human, Mouse.

Synonyms:
Cardiac-specific homeobox 1 antibody, Cardiac-specific homeobox antibody, CHNG5 antibody, CSX antibody, CSX1 antibody, FLJ52202 antibody, FLJ97166 antibody, FLJ97195 antibody, FLJ97197 antibody, FLJ99536 antibody, HLHS2 antibody, Homeobox protein CSX antibody, Homeobox protein NK-2 homolog E antibody, Homeobox protein Nkx 2.5 antibody, NK2 homeobox 5 antibody, NK2 transcription factor related locus 5 antibody, NK2 transcription factor related, locus 5 (Drosophila) antibody, Nkx2-5 antibody, NKX2.5 antibody, Nkx2E antibody, NKX4-1 antibody, Tinman paralog antibody, VSD3 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human Nkx2.5 (103-132aa AKDPRAEKKELCALQKAVELEKTEADNAER), different from the related mouse and rat sequences by five amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.