NKX2-5 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7797
Background:
Nkx-2.5, which is also designated cardiac specific homeobox protein (Csx), is a homeodomain-containing nuclear transcription protein of the Nkx-2 gene family. These transcriptional activators, which include thyroid transcription factor-1 (TTF-1), regulate the expression of tissue specific genes and are required for maintaining the differentiated phenotypes of various lineages. Nkx-2.5 is a homolog to the tinman protein expressed in Drosophila, and is essential for normal cardiovascular development. Expression of Nkx-2.5 during cardiomyogenesis is required for cardiac septation, in which a single atrium and ventricle are separated into four chambers. During embryonic development, Nkx-2.5 is also expressed in the foregut, thyroid, spleen and stomach, while in the adult expression is predominantly restricted to the heart. Mutations that disrupt Nkx-2.5 can result in atrial-septal defects, embryonic lethality and congenital heart disease.
Alternative Name:
Cardiac-specific homeobox 1, Cardiac-specific homeobox, CHNG5, CSX, CSX1, FLJ52202, FLJ97166, FLJ97195, FLJ97197, FLJ99536, HLHS2, Homeobox protein CSX, Homeobox protein NK-2 homolog E, Homeobox protein Nkx 2.5, NK2 homeobox 5, NK2 transcription factor related locus 5, NK2 transcription factor related, locus 5 (Drosophila), Nkx2-5, NKX2.5, Nkx2E, NKX4-1, Tinman paralog, VSD3,
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: NKX2-5 polyclonal antibody detects endogenous levels of NKX2-5 protein.
Immunogen:
Recombinant full length Human NKX2-5.
MW: ~ 35 kDa
Swis Prot.: P52952
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Nkx-2.5, which is also designated cardiac specific homeobox protein (Csx), is a homeodomain-containing nuclear transcription protein of the Nkx-2 gene family. These transcriptional activators, which include thyroid transcription factor-1 (TTF-1), regulate the expression of tissue specific genes and are required for maintaining the differentiated phenotypes of various lineages. Nkx-2.5 is a homolog to the tinman protein expressed in Drosophila, and is essential for normal cardiovascular development. Expression of Nkx-2.5 during cardiomyogenesis is required for cardiac septation, in which a single atrium and ventricle are separated into four chambers. During embryonic development, Nkx-2.5 is also expressed in the foregut, thyroid, spleen and stomach, while in the adult expression is predominantly restricted to the heart. Mutations that disrupt Nkx-2.5 can result in atrial-septal defects, embryonic lethality and congenital heart disease.
Alternative Name:
Cardiac-specific homeobox 1, Cardiac-specific homeobox, CHNG5, CSX, CSX1, FLJ52202, FLJ97166, FLJ97195, FLJ97197, FLJ99536, HLHS2, Homeobox protein CSX, Homeobox protein NK-2 homolog E, Homeobox protein Nkx 2.5, NK2 homeobox 5, NK2 transcription factor related locus 5, NK2 transcription factor related, locus 5 (Drosophila), Nkx2-5, NKX2.5, Nkx2E, NKX4-1, Tinman paralog, VSD3,
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: NKX2-5 polyclonal antibody detects endogenous levels of NKX2-5 protein.
Immunogen:
Recombinant full length Human NKX2-5.
MW: ~ 35 kDa
Swis Prot.: P52952
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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