NLRC4 Antibody (N-term) Blocking peptide
€363.00
In stock
SKU
AC-BP13307a
Background:
In C. elegans, Ced4 binds and activates Ced3, an apoptoticinitiator caspase, via caspase-associated recruitment domains(CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4(MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have atleast 1 N-terminal CARD domain followed by a centrally locatednucleotide-binding domain (NBD or NACHT) and a C-terminalregulatory domain, found only in mammals, that contains either WD40repeats or leucine-rich repeats (LRRs). CARD12 is a member of theCed4 family and can induce apoptosis.
Other Names:
NLR family CARD domain-containing protein 4, CARD, LRR, and NACHT-containing protein, Clan protein, Caspase recruitment domain-containing protein 12, Ice protease-activating factor, Ipaf, NLRC4, CARD12, CLAN, CLAN1, IPAF
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13307a was selected from the N-term region of NLRC4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: NLRC4
Gene ID: 58484
Primary Accession: Q9NPP4
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
In C. elegans, Ced4 binds and activates Ced3, an apoptoticinitiator caspase, via caspase-associated recruitment domains(CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4(MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have atleast 1 N-terminal CARD domain followed by a centrally locatednucleotide-binding domain (NBD or NACHT) and a C-terminalregulatory domain, found only in mammals, that contains either WD40repeats or leucine-rich repeats (LRRs). CARD12 is a member of theCed4 family and can induce apoptosis.
Other Names:
NLR family CARD domain-containing protein 4, CARD, LRR, and NACHT-containing protein, Clan protein, Caspase recruitment domain-containing protein 12, Ice protease-activating factor, Ipaf, NLRC4, CARD12, CLAN, CLAN1, IPAF
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13307a was selected from the N-term region of NLRC4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: NLRC4
Gene ID: 58484
Primary Accession: Q9NPP4
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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