NLRP10 Polyclonal Antibody

Background:
Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis.

Research Area: Cell biology, Immunology

Synonyms:
CLR11.1, NACHT, leucine rich repeat and PYD containing 10, NACHT, LRR and PYD domains containing protein 10, NACHT, LRR and PYD domains-containing protein 10, NAL10, NALP10, NLR family, pyrin domain containing 10, Nlrp10, NOD8, Nucleotide-binding oligomerization domain protein 8, Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10, PAN5, PYNOD

Immunogen: Synthetic peptide of human NLRP10

Swissprot: Q86W26
Gene Accession: NP_789791

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 1.2 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-50608/sc-50609