NLRP12 Polyclonal Antibody

Background:
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants.

Research Area: Cell Biology, Signal Transduction

Synonyms:
NLRP12, CLR19.3, FCAS2, NALP12, PAN6, PYPAF7, RNO, RNO2

Immunogen: Recombinant fusion protein of human NLRP12 (NP_001264055.1).

Swissprot: P59046
Gene ID: 91662

Calculated MW: 31 kDa/101 kDa/107 kDa/113 kDa/114 kDa/120 kDa
Observed MW: 120 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.