NLRP3/NALP3 (clone Cryo-2), anti-human, mouse

Decription:
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family, including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA).

Synonyms: NACHT-, LRR- and PYD-containing Protein 3, NLRP3, Cryopyrin, Cold Autoinflammatory Syndrome 1 Protein

Clone: Cryo-2

Isotype: Mouse IgG2b

Immunogen: Recombinant mouse NLRP3/NALP3 (pyrin domain/aa 1-93).

Reactivity: human, mouse

Specificity: Recognizes mouse and human NLRP3/NALP3.

Form: Purified, in PBS containing 10% glycerol and 0.02% sodium azide.

Applications: Western Blot: (1?g/ml)

Working Dilution: Optimal conditions must be determined individually for each application.

Concentration: 1mg/ml

Storage: 2-8C immediate use, or -20C (aliquote)