NLRP3 polyclonal, anti-human, mouse

Background:
Cryopyrin interacts selectively with apoptosis associated specklike protein containing a CARD domain (ASC). This complex may function as an upstream activator of NFkB signaling and caspase-1 activation. The complex also inhibits TNFa induced activation and nuclear translocation of RelA/NFkB p65. Mutations in Cryopyrin and Pyrin proteins are responsible for several autoinflammatory disorders in humans, including familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and chronic infantile neurologic cutaneous and articular syndrome (CINCA).

Alternative Name:
CLR1.1, NLRP3, C1orf7, CIAS1, NALP3, PYPAF1, AGTAVPRL, AII/AVP, Angiotensin/vasopressin receptor AII/AVP like, Angiotensin/vasopressin receptor AII/AVP-like, C1orf7, Caterpiller protein 1.1, CIAS 1, CIAS1, CLR1.1, Cold autoinflammatory syndrome 1, Cold autoinflammatory syndrome 1 protein, Cryopyrin, Familial cold autoinflammatory syndrome, FCAS, FCU, LRR and PYD domains-containing protein 3, Muckle-Wells syndrome, MWS, NACHT, NACHT LRR and PYD containing protein 3, NALP 3, NALP3, NALP3, NLR family pyrin domain containing 3, NLRP3, PYPAF 1, PYPAF1, PYRIN containing APAF1 like protein 1, PYRIN-containing APAF1-like protein 1,

Application Dilution:
WB:1:500-1:2,000
ICC:1:500-1:2,000
IHC:1:50-1:200
FC:1:50-1:100

Specificity: NLRP3 polyclonal antibody detects endogenous levels of NLRP3 protein.

Immunogen:
Peptide.

MW: 85 kDa

Swiss-Prot: Q96P20(Human) Q8R4B8(Mouse)

Purification & Purity:
Peptide affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.