NLRP3 polyclonal (N-term), anti-human

Background:
NLRP3 is a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis.

Other Names:
NACHT, LRR and PYD domains-containing protein 3, Angiotensin/vasopressin receptor AII/AVP-like, Caterpiller protein 11, CLR11, Cold autoinflammatory syndrome 1 protein, Cryopyrin, PYRIN-containing APAF1-like protein 1, NLRP3, C1orf7, CIAS1, NALP3, PYPAF1

Target/Specificity:
This NLRP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-91 amino acids from the N-terminal region of human NLRP3.

Antigen Region:
65-91

Antigen Type: Synthetic Peptide

Gene Name: NLRP3 {ECO:0000303|PubMed:17907925, ECO:0000312|HGNC:HGNC:16400}
Gene ID: 114548
Primary Accession: Q96P20
NCBI Accession: NP_001073289.1;NP_001120933.1;NP_001120934.1;NP_001230062.1;NP_004886.3;NP_899632.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.