NLRP4 Polyclonal Antibody

Background:
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes

Research Area: Cell Biology, Immunology

Synonyms:
Cancer/testis antigen 58, CLR19.5, CT58, FLJ32126, NACHT, leucine rich repeat and PYD containing 4, NACHT, LRR and PYD containing protein 4, NACHT, LRR and PYD domains-containing protein 4, NALP4, NLR family, pyrin domain containing 4, NLRP4, Nucleotide binding oligomerization domain, leucine rich repeat and pyrin domain containing 4, PAAD and NACHT containing protein 2, PAAD and NACHT-containing protein 2, PAN2, PYPAF4, PYRIN and NACHT-containing protein 2, PYRIN containing APAF1 like protein 4, PYRIN-containing APAF1-like protein 4, Ribonuclease inhibitor 2, RNH2

Immunogen: Synthetic peptide of human NLRP4

Swissprot: Q96MN2
Gene Accession: NP_604393

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.7 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-50620/sc-50623