NLRP6 Antibody (N-term) Blocking peptide
€363.00
In stock
SKU
AC-BP13529a
Background:
NALPs are cytoplasmic proteins that form a subfamilywithin the larger CATERPILLER protein family. Most short NALPs,such as NALP6, have an N-terminal pyrin (MEFV; MIM 608107) domain(PYD), followed by a NACHT domain, a NACHT-associated domain (NAD),and a C-terminal leucine-rich repeat (LRR) region. The long NALP,NALP1 (MIM 606636), also has a C-terminal extension containing afunction to find domain (FIIND) and a caspase recruitment domain(CARD). NALPs are implicated in the activation of proinflammatorycaspases (e.g., CASP1; MIM 147678) via their involvement inmultiprotein complexes called inflammasomes (Tschopp et al., 2003[PubMed 12563287]).
Other Names:
NACHT, LRR and PYD domains-containing protein 6, Angiotensin II/vasopressin receptor, PYRIN-containing APAF1-like protein 5, NLRP6, NALP6, PYPAF5
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13529a was selected from the N-term region of NLRP6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: NLRP6 {ECO:0000303|PubMed:21088234, ECO:0000312|HGNC:HGNC:22944}
Gene ID: 171389
Primary Accession: P59044
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
NALPs are cytoplasmic proteins that form a subfamilywithin the larger CATERPILLER protein family. Most short NALPs,such as NALP6, have an N-terminal pyrin (MEFV; MIM 608107) domain(PYD), followed by a NACHT domain, a NACHT-associated domain (NAD),and a C-terminal leucine-rich repeat (LRR) region. The long NALP,NALP1 (MIM 606636), also has a C-terminal extension containing afunction to find domain (FIIND) and a caspase recruitment domain(CARD). NALPs are implicated in the activation of proinflammatorycaspases (e.g., CASP1; MIM 147678) via their involvement inmultiprotein complexes called inflammasomes (Tschopp et al., 2003[PubMed 12563287]).
Other Names:
NACHT, LRR and PYD domains-containing protein 6, Angiotensin II/vasopressin receptor, PYRIN-containing APAF1-like protein 5, NLRP6, NALP6, PYPAF5
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13529a was selected from the N-term region of NLRP6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: NLRP6 {ECO:0000303|PubMed:21088234, ECO:0000312|HGNC:HGNC:22944}
Gene ID: 171389
Primary Accession: P59044
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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