NLRP6/NALP6 (clone Clint-1), anti-human

Decription:
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. NLRP6/NALP6 is important for intestinal homeostasis by sensing pathogenic commensal bacteria and activating bactericidal activity of macrophages through secretion of IL-18. NLRP6 suppresses inflammation and carcinogenesis by regulating tissue repair and deletion of NLRP6 gene accelerated colitis-associated tumor growth in mice.

Synonyms: NACHT-, LRR and PYD Domains-containing Protein 6, Nod-like Receptor Pyrin Domain-containing Protein 6, NLRP6, Angiotensin II/Vasopressin Receptor, PYRIN-containing APAF1-like Protein 5, NALP6

Clone: Clint-1

Isotype: Mouse IgG1 kappa

Immunogen: Recombinant human NLRP6 (NACHT domain).

Reactivity: human

Specificity: Recognizes human NLRP6.

Form: Purified, in PBS containing 10% glycerol and 0.02% sodium azide.

Applications: Western Blot: (1?g/ml)

Working Dilution: Optimal conditions must be determined individually for each application.

Concentration: 1mg/ml

Storage: 2-8C immediate use, or -20C (aliquote)