NLRP6 polyclonal (N-term), anti-human
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In stock
SKU
AC-AP13529a
Catalog Number: AC-AP13529a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB33587
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB33587
Applications: WB
Datasheet
Request Information
Background:
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP6, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).
Other Names:
NACHT, LRR and PYD domains-containing protein 6, Angiotensin II/vasopressin receptor, PYRIN-containing APAF1-like protein 5, NLRP6, NALP6, PYPAF5
Target/Specificity:
This NLRP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the N-terminal region of human NLRP6.
Antigen Region:
168-197
Antigen Type: Synthetic Peptide
Gene Name: NLRP6 {ECO:0000303|PubMed:21088234, ECO:0000312|HGNC:HGNC:22944}
Gene ID: 171389
Primary Accession: P59044
NCBI Accession: NP_001263629.1;NP_612202.2
Other Accession: NP_612202.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP6, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).
Other Names:
NACHT, LRR and PYD domains-containing protein 6, Angiotensin II/vasopressin receptor, PYRIN-containing APAF1-like protein 5, NLRP6, NALP6, PYPAF5
Target/Specificity:
This NLRP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the N-terminal region of human NLRP6.
Antigen Region:
168-197
Antigen Type: Synthetic Peptide
Gene Name: NLRP6 {ECO:0000303|PubMed:21088234, ECO:0000312|HGNC:HGNC:22944}
Gene ID: 171389
Primary Accession: P59044
NCBI Accession: NP_001263629.1;NP_612202.2
Other Accession: NP_612202.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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