NME3 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS72927
Background:
The nm23 protein is implicated in a variety of biological processes, including suppressing metastasis, phytochrome responses in plants and regulating differentiation. Nm23-H1, nm23-H2 and nm23-H2, members of the nm23 family, are putative metastasis suppressor genes that encode nucleoside diphosphate kinase (NDPK) A and B. NDPKs form oligomers, which are distributed in both the soluble and particulate fractions of cells. Upon cAMP-induced differentiation of rat cells, nm23 proteins show a differential interaction with intermediate filaments. Both isoforms also associate with GFAP in differentiated cells. nm23 proteins and their mutants are localized predominantly in the mitochondria. Nm23 mutants are unable to inhibit differentiation and promote apoptosis as a results of defective protein-protein interactions in the mitochondria.
Alternative Name:
c371H6.2, DR-nm23, NDPK-C, NDPKC, NM23-H3, NM23H3
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: NME3 polyclonal antibody detects endogenous levels of NME3 protein.
Immunogen:
Recombinant protein of human NME3
MW: 17kDa
Swis Prot.: Q13232
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The nm23 protein is implicated in a variety of biological processes, including suppressing metastasis, phytochrome responses in plants and regulating differentiation. Nm23-H1, nm23-H2 and nm23-H2, members of the nm23 family, are putative metastasis suppressor genes that encode nucleoside diphosphate kinase (NDPK) A and B. NDPKs form oligomers, which are distributed in both the soluble and particulate fractions of cells. Upon cAMP-induced differentiation of rat cells, nm23 proteins show a differential interaction with intermediate filaments. Both isoforms also associate with GFAP in differentiated cells. nm23 proteins and their mutants are localized predominantly in the mitochondria. Nm23 mutants are unable to inhibit differentiation and promote apoptosis as a results of defective protein-protein interactions in the mitochondria.
Alternative Name:
c371H6.2, DR-nm23, NDPK-C, NDPKC, NM23-H3, NM23H3
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: NME3 polyclonal antibody detects endogenous levels of NME3 protein.
Immunogen:
Recombinant protein of human NME3
MW: 17kDa
Swis Prot.: Q13232
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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