nNOS(neuronal) polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Nitric Oxide Synthase 1(NOS1,neuronal NOS,nNOS1) is a messenger molecule, mediating the effect of endothelium-derived relaxing factor in blood vessels and the cytotoxic actions of macrophages, and playing a part in neuronal communication in the brain. It may be involved in neuronal cell death and damage in neurological illness. nNOS1 localized to the 12q24.2 region of human chromosome 12. It splice variant, expressed in testis, that encodes an NH2-terminal truncated protein of 1098 amino acids. nNOS cDNA clones were shown to contain different 5' terminal exons spliced to a common exon 2. Genomic cloning and sequence analysis demonstrate that the unique exons are positioned within 300 bp of each other but separated from exon 2 by an intron that is at least 20 kb in length. The neuronal isoform of nitric oxide synthase is highly expressed in mammalian skeletal muscle, it suggested a specific role for NOS1 in the local metabolic inhibition of alpha-adrenergic vasoconstriction in active skeletal muscle. The novel gaseous neuromediator nitric oxide is though to play an important role in development and plasticity. Despite this, gene-knockout mice lacking neuronal(Type I) nitric oxide synthase exhibit relatively normal brain development and behavior.

Description:
Rabbit IgG polyclonal antibody for Nitric oxide synthase, brain (NOS1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
2310005C01Rik antibody, bNOS antibody, Constitutive NOS antibody, EC 1.14.13.39 antibody, IHPS 1 antibody, IHPS1 antibody, N NOS antibody, N-NOS antibody, NC NOS antibody, NC-NOS antibody, neuronal Nitric Oxide Synthase antibody, Neuronal NOS antibody, Nitric oxide synthase, neuronal, included antibody, Nitric oxide synthase 1(neuronal) antibody, Nitric oxide synthase 1 antibody, Nitric oxide synthase brain antibody, Nitric oxide synthase, brain antibody, Nitric oxide synthase, penile neuronal, included antibody, nNOS antibody, NO antibody, NOS 1 antibody, NOS antibody, NOS type I antibody, NOS-I antibody, NOS1 antibody, NOS1_HUMAN antibody, Peptidyl-cysteine S-nitrosylase NOS1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human nNOS(neuronal)(1418-1434aa IAFIEESKKDTDEVFSS), identical to the related mouse and rat sequences.A synthetic peptide corresponding to a sequence at the C-terminus of human nNOS(neuronal)(1418-1434aa IAFIEESKKDTDEVFSS), identical to the related mouse and rat sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.