NNT polyclonal, anti-human, mouse
€305.00
In stock
SKU
BS60186
Background:
The proccess of cellular respiration is carried out by integral inner mitochondrial membrane proteins that facilitate the harnessing of energy released by the oxidation of NADH. NNT (Nicotinamide nucleotide transhydrogenase), also known as mitochondrial NAD(P) transhydrogenase or pyridine nucleotide transhydrogenase, is a 1086 amino acid multi-pass mitochondrial inner membrane protein. NNT is a homodimer with an N-terminal section belonging to the AlaDH/PNT family and a C-terminal section belonging to the PNT β subunit family. NNT catalyzes the transfer of a hydride ion from NADH to NADP+ and functions as a mitochondrial inner membrane proton pump. Using the energy of the proton gradient created by the electron transport chain, NNT produces high concentrations of NADPH, which is used in free radical detoxification and biosynthesis.
Alternative Name:
NAD(P) transhydrogenase, mitochondrial, Nicotinamide nucleotide transhydrogenase, Pyridine nucleotide transhydrogenase
Application Dilution: WB: 1:500~1:1000
Specificity: NNT polyclonal antibody detects endogenous levels of NNT protein.
Immunogen:
A synthetic peptide corresponding to residues in Human NNT.
MW: ~ 114 kDa
Swis Prot.: Q13423
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The proccess of cellular respiration is carried out by integral inner mitochondrial membrane proteins that facilitate the harnessing of energy released by the oxidation of NADH. NNT (Nicotinamide nucleotide transhydrogenase), also known as mitochondrial NAD(P) transhydrogenase or pyridine nucleotide transhydrogenase, is a 1086 amino acid multi-pass mitochondrial inner membrane protein. NNT is a homodimer with an N-terminal section belonging to the AlaDH/PNT family and a C-terminal section belonging to the PNT β subunit family. NNT catalyzes the transfer of a hydride ion from NADH to NADP+ and functions as a mitochondrial inner membrane proton pump. Using the energy of the proton gradient created by the electron transport chain, NNT produces high concentrations of NADPH, which is used in free radical detoxification and biosynthesis.
Alternative Name:
NAD(P) transhydrogenase, mitochondrial, Nicotinamide nucleotide transhydrogenase, Pyridine nucleotide transhydrogenase
Application Dilution: WB: 1:500~1:1000
Specificity: NNT polyclonal antibody detects endogenous levels of NNT protein.
Immunogen:
A synthetic peptide corresponding to residues in Human NNT.
MW: ~ 114 kDa
Swis Prot.: Q13423
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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