Nod1 (AL184) polyclonal, anti-human

Quantity: 100 µl

Description:
Nod (CARD4) is a cytosolic pattern recognition molecule (PRRs) of the NLR (NOD-like receptor) family. Nod1 is widely expressed by many cell types and is implicated in sensing meso-diaminopimelic acid (meso-DAP)-containing PGN fragments, which are present in most Gramnegative bacteria and certain Gram-positive ones, like the Bacillus species. Upon activation, Nod1 initiates a pro-inflammatory response through NF-kappa signaling and is a key receptors in epithelial cells where it controls infections via the gastrointestinal system. Mutations in Nod1 have been reported to confer susceptibility to several inflammatory disorders including inflammatory bowel disease, atopic eczema and asthma.

Synonyms:
CARD4, Caspase Recruitment Domain-containing Protein 4, Nucleotide-binding Oligomerization Domain-containing Protein 1

Isotype: Rabbit Polyclonal

Immunogen:
Synthetic peptide corresponding to aa 2-31 (E2EQGHSEMEIIPSESHPHIQLLKSNRELLV31) of human Nod1.

Form: Purified, in PBS containing 10% glycerol and 0.02% sodium azide.

Specificity:
Recognizes human Nod1.

Reactivity: human

Applications: Western Blot

Working DIlution: Optimal conditions must be determined individually for each application.

Storage: 2-8C immediate use, or -20C (aliquoted)