NOD5 polyclonal, anti-human, mouse, rat
€484.00
In stock
SKU
254342
Protein Family: Enzymes
Pathway and Disease: Signaling Molecules and Interaction
Description:
NOD5, also known as NLRX1, is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD5 localizes to the mitochondrial outer membrane and interacts with the virus-induced signaling adapter protein VISA. Unlike a subset of NOD-like receptors (NLRs) such as NOD1 and NOD2 which trigger pro-inflammatory cascades, and other NLRs that induce the caspase 1 inflammasome in response to immune challenges, NOD5 amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production.
Alternate Names: NOD5, Nucleotide-binding oligomerization domain containing 5, NOD9, NOD26, DLNB26, CLR11.3, NLRX1
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_078894
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human NOD5.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction
Description:
NOD5, also known as NLRX1, is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD5 localizes to the mitochondrial outer membrane and interacts with the virus-induced signaling adapter protein VISA. Unlike a subset of NOD-like receptors (NLRs) such as NOD1 and NOD2 which trigger pro-inflammatory cascades, and other NLRs that induce the caspase 1 inflammasome in response to immune challenges, NOD5 amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production.
Alternate Names: NOD5, Nucleotide-binding oligomerization domain containing 5, NOD9, NOD26, DLNB26, CLR11.3, NLRX1
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_078894
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human NOD5.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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