Noggin Polyclonal Antibody
€0.00
In stock
SKU
ELK-ES8751
Catalog Number: ELK-ES8751
Reactivity: Human, Mouse, Rat
Applications: IHC-p, ELISA
Information
Request Manual ELK-
Questions? Contact us!
Reactivity: Human, Mouse, Rat
Applications: IHC-p, ELISA
Information
Request Manual ELK-
Questions? Contact us!
Background:
noggin(NOG) Homo sapiens The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and mu
Alternative Names:
Noggin
Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human NOG. AA range:21-70
Isotype: Rabbit
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/ml
GeneID: NOG
Storage: -20°C/1 year
NOTE: For Research Use Only
noggin(NOG) Homo sapiens The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and mu
Alternative Names:
Noggin
Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human NOG. AA range:21-70
Isotype: Rabbit
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/ml
GeneID: NOG
Storage: -20°C/1 year
NOTE: For Research Use Only
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