Nogo A polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Human neurite outgrowth inhibitor(NOGO) cDNAs encodes 3 splice variants: NOGOA, NOGOB and NOGOC. The longest cDNA, designated NOGOA, has an open reading frame of 1192 amino acids. It is a potent inhibitor of neurite growth and an IN-1 antigen produced by oligodendrocytes, and may allow the generation of new reagents to enhance CNS regeneration and plasticity. Nogo-A, a member of the Reticulon family, is expressed by oligodendrocytes and associates primarily with the endoplasmic reticulum. The acidic amino terminus of Nogo-A is detected at the cytosolic face of cellular membranes and may contribute to inhibition of axon regeneration at sites of oligodendrocyte injury. A multivalent form of the N terminus of Nogo-A affects the morphology of both neurons and other cell types.

Description:
Rabbit IgG polyclonal antibody for Reticulon-4 (RTN4) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
ASY antibody, Foocen antibody, Human NogoA antibody, KIAA0886 antibody, My043 protein antibody, Nbla00271 antibody, Nbla10545 antibody, Neurite growth inhibitor 220 antibody, Neurite Outgrowth Inhibitor antibody, Neuroendocrine specific protein antibody, Neuroendocrine specific protein C homolog antibody, Neuroendocrine-specific protein antibody, Neuroendocrine-specific protein C homolog antibody, NI220/250 antibody, Nogo A antibody, NOGO antibody, Nogo protein antibody, NOGO-A antibody, Nogo-B antibody, Nogo-C antibody, NogoA antibody, NSP antibody, NSP CL antibody, NSP-CL antibody, Reticulon 4 antibody, Reticulon 5 antibody, Reticulon-4 antibody, Reticulon-5 antibody, Reticulon4 antibody, Reticulon5 antibody, RTN 4 antibody, RTN 4A antibody, RTN X antibody, RTN xL antibody, RTN-x antibody, RTN4 A antibody, RTN4 antibody, RTN4 B1 antibody, RTN4 B2 antibody, RTN4 C antibody, RTN4 protein antibody, RTN4-A antibody, RTN4-B1 antibody, RTN4-B2 antibody, RTN4-C antibody, RTN4_HUMAN antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Nogo A(1170-1192aa NKNVKDAMAKIQAKIPGLKRKAE), different from the related rat sequence by two amino acids, and from the related mouse sequence by one amino acid.A synthetic peptide corresponding to a sequence at the C-terminus of human Nogo A(1170-1192aa NKNVKDAMAKIQAKIPGLKRKAE), different from the related rat sequence by two amino acids, and from the related mouse sequence by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: mouse, rat.
Predicted to work with: human.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.