Nogo B polyclonal, anti-human, mouse

Background:
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.

Alternative Name:
Nogo protein, NSP, RTN4, KIAA0886, NOGO, My043, SP1507, 1110020G17Rik, AA407876, AA409940, AA960376, ASY, C130026I10Rik, Foocen, Glut4 vesicle 20 kDa protein, Human NogoA, Kiaa0886, KIAA4153, MGC116054, MGC139261, mKIAA0886, mKIAA4153, My043 protein, Nbla00271, Nbla10545, Neurite growth inhibitor 220, Neurite Growth Inhibitor 220, included, Neurite outgrowth inhibitor, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, NI-250, NI220/250, Nogo A, NOGO, Nogo B, Nogo C, Nogo protein, NOGOC, NSP, NSP-CL, rat N, Reticulon 4, Reticulon 5, Reticulon-4, Reticulon-5, RTN X, RTN-x, Rtn4, Rtn4 reticulon 4, RTN4-A, RTN4-B1, RTN4-B2, RTN4-C, RTN4, Vp20,

Application Dilution:
WB:1:500-1:2,000
ICC/IF:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100
IP:1:10-1:50

Specificity: Nogo B polyclonal antibody detects endogenous levels of Nogo B protein.

Immunogen:
Recombinant protein

Swiss-Prot: Q9NQC3(Human) Q99P72(Mouse)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.