NOGO polyclonal, anti-human, mouse, rat

Protein Family: Cytokines

Pathway and Disease: Signaling Molecules and Interaction, Cell Growth and Death, Nervous and Sensory Systems

Description:
Neurite outgrowth inhibitor (NOGO) plays a role both in the restriction of axonal regeneration after injury and in structural plasticity in the CNS. Isoform 2 of NOGO reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 of NOGO inhibit BACE1 activity and amyloid precursor protein processing.

Alternate Names: Nogo protein, Reticulon-4, Neurite outgrowth inhibitor, Foocen, Neuroendocrine-specific protein, NSP, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5, RTN4, KIAA0886, NOGO

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: Q9NQC3

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human NOGO.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.