NORE1 Antibody (C-term) Blocking peptide
€363.00
In stock
SKU
AC-BP11698b
Background:
The protein encoded by this gene is highly similar to thegene product of Schizosaccharomyces pombe rad17, a cell cyclecheckpoint gene required for cell cycle arrest and DNA damagerepair in response to DNA damage. This protein shares strongsimilarity with DNA replication factor C (RFC), and can form acomplex with RFCs. This protein binds to chromatin prior to DNAdamage and is phosphorylated by the checkpoint kinase ATR followingdamage. This protein recruits the RAD1-RAD9-HUS1 checkpoint proteincomplex onto chromatin after DNA damage, which may be required forits phosphorylation. The phosphorylation of this protein isrequired for the DNA-damage-induced cell cycle G2 arrest, and isthought to be a critical early event during checkpoint signaling inDNA-damaged cells. Eight alternatively spliced transcript variantsof this gene, which encode four distinct proteins, have beenreported. Two pseudogenes, located on chromosomes 7 and 13, havebeen identified.
Other Names:
Ras association domain-containing protein 5, New ras effector 1, Regulator for cell adhesion and polarization enriched in lymphoid tissues, RAPL, RASSF5, NORE1, RAPL
Gene Name: RASSF5
Gene ID: 83593
Primary Accession: Q8WWW0
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The protein encoded by this gene is highly similar to thegene product of Schizosaccharomyces pombe rad17, a cell cyclecheckpoint gene required for cell cycle arrest and DNA damagerepair in response to DNA damage. This protein shares strongsimilarity with DNA replication factor C (RFC), and can form acomplex with RFCs. This protein binds to chromatin prior to DNAdamage and is phosphorylated by the checkpoint kinase ATR followingdamage. This protein recruits the RAD1-RAD9-HUS1 checkpoint proteincomplex onto chromatin after DNA damage, which may be required forits phosphorylation. The phosphorylation of this protein isrequired for the DNA-damage-induced cell cycle G2 arrest, and isthought to be a critical early event during checkpoint signaling inDNA-damaged cells. Eight alternatively spliced transcript variantsof this gene, which encode four distinct proteins, have beenreported. Two pseudogenes, located on chromosomes 7 and 13, havebeen identified.
Other Names:
Ras association domain-containing protein 5, New ras effector 1, Regulator for cell adhesion and polarization enriched in lymphoid tissues, RAPL, RASSF5, NORE1, RAPL
Gene Name: RASSF5
Gene ID: 83593
Primary Accession: Q8WWW0
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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