NOS-2 polyclonal, anti-human, mouse, rat

Protein Family: Enzymes

Pathway and Disease: Amino Acid Metabolism, Cancers, Nervous and Sensory Systems, Neurodegenerative Disorders, Signal Transduction

Description:
Nitric oxide synthases (NOS) are enzymes that catalyze the generation of nitric oxide (NO) from L-arginine and require nicotinamide adenine dinucleotide phosphate (NADPH) as a cofactor. At least three NOS isoforms have been identified: neuronal NOS (nNOS or NOS1 or bNOS), inducible NOS (iNOS or NOSII) and endothelial NOS (eNOS or NOS III). NOS-2 produces NO which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions.

Alternate Names: Nitric oxide synthase, inducible, Inducible NO synthase, inducible NOS, iNOS, NOS type II, Hepatocyte NOS, HEP-NOS, NOS2, NOS2A, NOS-2

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:200-1:500

Accession No.: P35228

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human NOS-2.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.