NOS-3 polyclonal, anti-human, mouse, rat

Protein Family: Enzymes

Pathway and Disease: Amino Acid Metabolism, Signal Transduction, Signaling Molecules and Interaction

Description:
eNOS (Endothelial NOS) is a nitric oxyde synthase enzyme, part of the Nitric oxyde pathway. Nitric oxide synthases (NOS) are enzymes that catalyze the generation of nitric oxide (NO) from L-arginine and require nicotinamide adenine dinucleotide phosphate (NADPH) as a cofactor. At least three isioforms of NOS have been idenified: neuronal NOS (nNOS), endothelial NOS (eNOS), and inducible NOS (iNOS). NOS-3 (eNOS, endothelial NOS) produces NO which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.

Alternate Names: NOS-3, eNOS, Endothelial NOS, Nitric oxide synthase, endothelial, EC-NOS, NOS type III, NOSIII, Constitutive NOS, cNOS, NOS3

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; IF: 1:100-1:500

Accession No.: P29474

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human NOS-3.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.