NOS1 Polyclonal Antibody

Background:
The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.

Research Area: Cancer, Metabolism, Neuroscience

Synonyms:
2310005C01Rik, BNOS, Constitutive NOS, EC 1.14.13.39, IHPS 1, IHPS1, N-NOS, NC-NOS, neuronal Nitric Oxide Synthase, Neuronal NOS, Nitric oxide synthase, neuronal, included, Nitric oxide synthase 1 (neuronal), Nitric oxide synthase 1, Nitric oxide synthase, brain, Nitric oxide synthase, penile neuronal, included, NNOS, NO, NOS 1, NOS, NOS type I, NOS-I, NOS1, NOS1, Peptidyl-cysteine S-nitrosylase NOS1

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse nNOS

Swissprot: P29475,P29476,Q9Z0J4

Calculated MW: 161 kDa
Observed MW: 161 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Concentration: 350 μg/mL
Dilution: WB 1:500-1:2000, IHC 1:300-1:800

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Citation(s):
https://www.nrcresearchpress.com/doi/abs/10.1139/apnm-2018-0702