NOSIP polyclonal, anti-human
€388.00
In stock
SKU
BS71005
Background:
Endothelial nitric oxide synthase (eNOS) interacting protein (NOSIP) is a modulator of eNOS activity. eNOS is an important nitric oxide (NO)-generating enzyme of the vasculature that is regulated by interactions with caveolin-1, Ca2+-calmodulin, HSP 90 and NOSIP. NOSIP modulates this activity by promoting the translocation of eNOS from the plasma membrane to intracellular sites, which in turn inhibits NO synthesis. NOSIP is involved in controlling airway and vascular diameter, synthesis of NO in ciliated epithelia and mucosal secretion, and is an important protein for mucociliary and bronchial function. NOSIP is highly expressed in endothelial cells and vascularized tissue.
Alternative Name:
CGI-25, Nitric oxide synthase-interacting protein
Application Dilution: WB: 1:500 - 1:2000
Specificity: NOSIP polyclonal antibody detects endogenous levels of NOSIP protein.
Immunogen:
Recombinant protein of human NOSIP.
MW: ~ 33 kDa
Swis Prot.: Q9Y314
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Endothelial nitric oxide synthase (eNOS) interacting protein (NOSIP) is a modulator of eNOS activity. eNOS is an important nitric oxide (NO)-generating enzyme of the vasculature that is regulated by interactions with caveolin-1, Ca2+-calmodulin, HSP 90 and NOSIP. NOSIP modulates this activity by promoting the translocation of eNOS from the plasma membrane to intracellular sites, which in turn inhibits NO synthesis. NOSIP is involved in controlling airway and vascular diameter, synthesis of NO in ciliated epithelia and mucosal secretion, and is an important protein for mucociliary and bronchial function. NOSIP is highly expressed in endothelial cells and vascularized tissue.
Alternative Name:
CGI-25, Nitric oxide synthase-interacting protein
Application Dilution: WB: 1:500 - 1:2000
Specificity: NOSIP polyclonal antibody detects endogenous levels of NOSIP protein.
Immunogen:
Recombinant protein of human NOSIP.
MW: ~ 33 kDa
Swis Prot.: Q9Y314
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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