NOTCH1 polyclonal, anti-human, mouse, rat

Background:
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.

Synonyms: AOS5, AOVD1, TAN1, hN1

Cellular Location: Cell membrane Nucleus Single-pass type I membrane protein

Immunogen:
A synthetic peptide of human NOTCH1

Gene Symbol: NOTCH1

Gene ID: 4851

Swiss prot: P46531

Calculated MW: 273kDa

Recommended dilution:
WB 1:500-2000, IHC 1:100-200, IF 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.