NOTCH3 monoclonal (C-term Q2306), anti-human
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In stock
SKU
AC-AM2059b
Catalog Number: AC-AM2059b
Size: 80 µl, 400 µl
Isotype: mouse IgG1
Clone Name: 487CT6.9.2
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: mouse IgG1
Clone Name: 487CT6.9.2
Applications: WB
Datasheet
Request Information
Background:
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq].
Other Names:
Neurogenic locus notch homolog protein 3, Notch 3, Notch 3 extracellular truncation, Notch 3 intracellular domain, NOTCH3
Target/Specificity:
This NOTCH3 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 2291-2321 amino acids from the C-terminal region of human NOTCH3.
Antigen Region:
2291-2321
Antigen Type: Synthetic Peptide
Gene Name: NOTCH3
Gene ID: 4854
Primary Accession: Q9UM47
NCBI Accession: NP_000426.2
Other Accession: NP_000426.2
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq].
Other Names:
Neurogenic locus notch homolog protein 3, Notch 3, Notch 3 extracellular truncation, Notch 3 intracellular domain, NOTCH3
Target/Specificity:
This NOTCH3 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 2291-2321 amino acids from the C-terminal region of human NOTCH3.
Antigen Region:
2291-2321
Antigen Type: Synthetic Peptide
Gene Name: NOTCH3
Gene ID: 4854
Primary Accession: Q9UM47
NCBI Accession: NP_000426.2
Other Accession: NP_000426.2
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
| Is Featured? | No |
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