NOTCH3 polyclonal, anti-rat

Background:
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Synonyms: CADASIL, CADASIL1, CASIL, IMF2, LMNS

Cellular Location: Cell membrane Nucleus Single-pass type I membrane protein

Immunogen:
Recombinant Protein of human NOTCH3

Gene Symbol: NOTCH3

Gene ID: 4854

Swiss prot: Q9UM47

Calculated MW: 244kDa

Recommended dilution:
WB 1:500-2000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.