NOTCH3 Polyclonal Antibody

Background:
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Research Area: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Neuroscience, Stem Cells

Synonyms:
CADASIL, CASIL, NOTC3, Notch 3, Notch 3 intracellular domain, Notch homolog 3, Notch3

Immunogen: Synthetic peptide of human NOTCH3

Swissprot: Q9UM47
Gene Accession: NP_000426

Calculated MW: 244 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.3 mg/mL
Dilution: WB 1:200-1:1000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-7424/sc-5593