NOTCH4 Blocking Peptide (C-term)
€363.00
In stock
SKU
AC-BP21426b
Background:
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity).
Other Names:
Neurogenic locus notch homolog protein 4, Notch 4, hNotch4, Notch 4 extracellular truncation, Notch 4 intracellular domain, NOTCH4, INT3
Target/Specificity:
The synthetic peptide sequence is selected from aa 1819-1831 of HUMAN NOTCH4
Gene Name: NOTCH4 (HGNC:7884)
Gene ID: 4855
Primary Accession: Q99466
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity).
Other Names:
Neurogenic locus notch homolog protein 4, Notch 4, hNotch4, Notch 4 extracellular truncation, Notch 4 intracellular domain, NOTCH4, INT3
Target/Specificity:
The synthetic peptide sequence is selected from aa 1819-1831 of HUMAN NOTCH4
Gene Name: NOTCH4 (HGNC:7884)
Gene ID: 4855
Primary Accession: Q99466
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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