NOTCH4 polyclonal, anti-human, mouse

Background:
The LIN-12/Notch transmembrane receptors are believed to play a central role in development by regulating cell fate decisions. Four Notch homologs (Notch 1, Notch 2, Notch 3 and Notch 4) have been identified in mammals. The Notch genes are expressed in a variety of embryonic and adult tissues, suggesting that the genes are involved in multiple signaling pathways. Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged1, Jagged2 and Delta. Jagged1 can activate Notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes. Jagged2 may be involved in tissue development that is dependent upon epithelial-mesenchymal interactions. In addition to its normal expression in the adrenal gland and placenta, Delta expression has also been found in neuroendocrine tumors.

Alternative Name:
Notch 4, hNotch4, NOTCH4, FLJ16302, hNotch 4, hNotch4, INT3, Neurogenic locus notch homolog protein 4, NOTC4, Notch 4, Notch 4 intracellular domain, Notch homolog 4, NOTCH3, Notch4, NOTCH4 protein,

Application Dilution:
WB:1:500-1:1,000
FC:1:50-1:100

Specificity: NOTCH4 polyclonal antibody detects endogenous levels of NOTCH4 protein.

Immunogen:
recombinant protein

MW: 210 kDa

Swiss-Prot: Q99466(Human) P31695(Mouse)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -81°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.