NOX1 polyclonal, anti-human

Quantity: 100 µg

Background:
NOX1(NADPH OXIDASE 1), also known as NOH1, MOX1 or GP91-2, is an enzyme that in humans is encoded by the NOX1 gene. It is also a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. The NOX1 gene is mapped to Xq22.1. NOX1 was expressed in colon, prostate, uterus, and vascular smooth muscle, but not in peripheral blood leukocytes. The deduced 564-amino acid NOX1 protein, which is 58% identical to CYBB, contains 6 membrane-spanning regions, conserved flavin and pyridine nucleotide-binding sites, and histidines possibly involved in heme ligation. Overexpression of MOX1 in NIH 3T3 cells increased superoxide generation and cell growth. Cells expressing MOX1 had a transformed appearance, showed anchorage-independent growth, and produced tumors in athymic mice. Disruption of either Nox1 or Nox2 significantly delayed progression of motor neuron disease in these mice. However, 50% survival rates were enhanced significantly more by Nox2 deletion than Nox1 deletion.

Description:
Rabbit IgG polyclonal antibody for NADPH oxidase 1 (NOX1) detection. Tested with WB, IHC-P in Human.

Synonyms:
GP91 2 antibody, Mitogenic oxidase(pyridine nucleotide dependent superoxide generating) antibody, Mitogenic oxidase 1 antibody, MOX-1 antibody, MOX1 antibody, NADH/NADPH mitogenic oxidase subunit P65 MOX antibody, NADH/NADPH mitogenic oxidase subunit P65-MOX antibody, NADPH oxidase 1 antibody, NADPH oxidase 1 variant NOH 1L antibody, NADPH oxidase homolog 1 antibody, NOH 1 antibody, NOH-1 antibody, NOH1 antibody, NOX-1 antibody, Nox1 antibody, NOX1_HUMAN antibody, RP1 146H21.1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human NOX1(354-374aa, HIRAAGDWTENLIRAFEQQYS).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.