NOX4 / NADPH Oxidase 4 (clone NOX4/1245), anti-human
€0.00
In stock
SKU
AC-AH13419
Catalog Number: AC-AH13419
Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: NOX4/1245
Applications: WB, IF, FC, E
Datasheet
Request Information
Size: 20 µg, 100 µg
Isotype: Mouse
Clone Name: NOX4/1245
Applications: WB, IF, FC, E
Datasheet
Request Information
Background:
The superoxide-generating NADPH oxidase includes a membrane-bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane where they associate with the flavocytochrome, cytochrome b558, to form the active enzyme complex. The p22 and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions. NOX4 is a renal gp91-phox homolog highly expressed at the site of erythropoietin production in the proximal convoluted tubule epithelial cells of the renal cortex. It is also expressed in fetal tissues, placenta, glioblastoma and vascular cells.
Other Names:
Kidney oxidase-1; Kidney superoxide-producing NADPH oxidase; KOX-1; NADPH oxidase 4; Nox4; Renal NAD(P)H-oxidase; RENOX
Antigen Type:
Recombinant protein
Gene Name: NOX4
Gene ID: 50507
Primary Accession: Q9NPH5
Other Accession: 371036
The superoxide-generating NADPH oxidase includes a membrane-bound flavocytochrome containing two subunits, gp91-phox and p22-phox, and the cytosolic proteins p47-phox and p67-phox. During activation of the NADPH oxidase, p47-phox and p67-phox migrate to the plasma membrane where they associate with the flavocytochrome, cytochrome b558, to form the active enzyme complex. The p22 and gp91-phox subunits also function as surface O2 sensors that initiate cellular signaling in response to hypoxic conditions. NOX4 is a renal gp91-phox homolog highly expressed at the site of erythropoietin production in the proximal convoluted tubule epithelial cells of the renal cortex. It is also expressed in fetal tissues, placenta, glioblastoma and vascular cells.
Other Names:
Kidney oxidase-1; Kidney superoxide-producing NADPH oxidase; KOX-1; NADPH oxidase 4; Nox4; Renal NAD(P)H-oxidase; RENOX
Antigen Type:
Recombinant protein
Gene Name: NOX4
Gene ID: 50507
Primary Accession: Q9NPH5
Other Accession: 371036
| Is Featured? | No |
|---|
Write Your Own Review